Melanoma: A Deadly Disease
The statistics are staggering. In the U.S., someone is diagnosed with melanoma every eight minutes. Each hour, one American will lose their life due to melanoma. The lifetime risk of developing melanoma has increased to one in 50 Americans. In the 1950s, it was 1 in 1,500. Melanoma is quickly becoming one of the deadliest skin cancers if not caught in the early stages.
What is Melanoma?
Melanoma involves cells called melanocytes, which produce a skin pigment called melanin. Melanin is responsible for skin and hair color.
Causes of Melanoma
There are four major types of melanoma:
- The most common type of melanoma is superficial spreading melanoma. It is usually flat and irregular in shape and color, with varying shades of black and brown. It may occur at any age or body site, and is most common in Caucasians.
- Nodular melanoma usually starts as a raised area that is dark blackish-blue or bluish-red, although some are
- Lentigo maligna melanoma usually occurs in the elderly. It is most common in sun-damaged skin on the face, neck, and arms. The abnormal skin areas are usually large, flat, and tan with intermixed areas of brown.
- Acral lentiginous melanoma is the least common form of melanoma. It usually occurs on the palms, soles, or under the nails and is more common in African Americans.
The risk of developing melanoma increases with age, but the disease also frequently affects young, otherwise healthy people.
Melanoma may appear on normal skin, or it may begin at a mole or other area that has changed in appearance. Some moles present at birth may develop into melanomas.
The development of melanoma is related to sun exposure, particularly to sunburns during childhood. It is most common among people with fair skin, blue or green eyes, and red or blond hair.
Risk factors include the following:
- Family history of melanoma
- Red or blond hair and fair skin
- Presence of multiple birthmarks
- Development of precancerous sores
- Obvious freckling on the upper back
- Three or more blistering sunburns before age 20
- Three or more years spent at an outdoor summer job as a teenager
- High levels of exposure to strong sunlight
The ABCD system may help you remember features that might be symptoms of melanoma:
- Asymmetry: One half of the abnormal area is different from the other half.
- Borders: The lesion or growth has irregular edges.
- Color: Color changes from one area to another, with shades of tan, brown, or black (sometimes white, red, or blue). A mixture of colors may appear within one sore.
- Diameter: The trouble spot is usually (but not always) larger than 6 mm in diameter -- about the size of a
Test & Diagnosis
The American Cancer Society recommends professional skin examinations every year for people older than 40,
and every 3 years for people aged 20 - 40. Monthly self-examination is also recommended.
Your health care provider may suspect melanoma based on the appearance of the growth, sore, or lump. A biopsy may be used to confirm the diagnosis. The biopsy may involve removal of a small area of a growth, or the entire growth itself.
lymph node biopsy may be necessary to check if the cancer has spread to nearby lymph nodes. If it has, these lymph nodes may also need to be removed.
The smallest and most shallow melanomas can be cured by surgery alone, so early diagnosis is very important.
Radiation therapy, chemotherapy, or immunotherapy (use of medications that stimulate the immune system, such as interferon) may be recommended in addition to surgery.
For patients with melanoma that has spread beyond the skin and lymph nodes to other organs, treatment is more difficult. At this point, treatment is usually directed at shrinking the tumor and improving symptoms. Both chemotherapy and use of interferon or interleukin may be tried. These patients also should consider participating in clinical trials.
As of February 2016, new immunotheraphy drugs have become available as standard treatment options for some melanoma patients.
If caught early, melanoma can be cured. The risk of the cancer coming back increases with the depth of the tumor - deeper tumors are more likely to come back. If the cancer has spread to lymph nodes, there is a greater chance that the melanoma will come back.
For melanoma that has spread to other tissues and organs, the cure rate is low. Melanoma that has spread may lead to death.
Complications of melanoma include the following:
When to Contact a Doctor
Call your health care provider if you notice any symptoms of melanoma, particularly the following: